Fachada_MARCOMARCO was designed by Mexican architect Ricardo Legorreta, in a Minimalist Post-modern architectural style. The museum building opened in 1991.

The artworks are in spaces with balanced arrangements of natural and artificial light.

The museum occupies a 16,000 square metres (170,000 sq ft) structure, with 5,000 square metres (54,000 sq ft) for exhibitions in 11 gallery halls. There is an outdoor sculpture garden courtyard, the Central Patio courtyard with a water mirror fountain, and an auditorium, gift shop and restaurant.

A large outdoor bronze sculpture is a landmark at the museum’s entrance plaza on the street. It is an abstracted dove, titled “La Paloma” (the dove), by sculptor Juan Soriano. The 4 ton modern sculpture rises 18 feet (5.5 m) above the plaza and street corner of Zuazua and Jardón streets.